Forbedringer i chemosensorik og kardiometabolisme efter faste?
Obesity is linked to decreased chemosensory acuity and elevated disease risk, highlighting the need for interventions targeting smell, taste, and cardiometabolic markers. A recent randomized controlled trial investigated the effects of a fasting-mimicking diet (FMD) on these parameters in individuals with overweight or obesity, as detailed in Cell Rep Med (2025) [source_link].
The study employed a randomized cross-over design involving 102 participants with overweight/obesity. Each subject underwent six monthly cycles of a 5-day FMD, followed by a normal diet for the remainder of the month. This design allowed researchers to assess the effects of FMD on chemosensory functions and cardiometabolic risk factors over time.
Primary endpoints included changes in chemosensory perception, specifically taste and smell acuity, while secondary endpoints involved cardiometabolic and inflammatory markers. The analysis revealed significant improvements in chemosensory functions; the proportion of hyposmic individuals decreased from 38.1% at baseline to 6.4% after six FMD cycles. Furthermore, FMD cycles were associated with reductions in cardiometabolic risk factors and medication use among diabetic patients. The trial was registered with ClinicalTrials.gov (NCT04529161).
Dette er en AI-genereret oversættelse og opsummering. Læseren bør konsultere den originale kilde for validering og ikke træffe kliniske beslutninger udelukkende på baggrund af dette resumé.
#InternMedicinsk #Endokrinologi #KliniskFysiologi #Diabetologi #Fodringsmedicin
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